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Folder: concepts

346 items under this folder.

Mar 31, 2026
ABC bypasses likelihood evaluation through data simulation
Mar 31, 2026
ABC enables model selection through comparison of observed and simulated data
Mar 31, 2026
ABC frameworks balance computational tractability with inferential precision through architectural tradeoffs
Mar 31, 2026
AneuFinder enables automated quantification of copy number heterogeneity
Mar 31, 2026
Aneuploid cancers inactivate Stat1 to circumvent immune surveillance
Mar 31, 2026
Aneuploid tumors inactivate Stat1 signaling with increased Myc activity
Mar 31, 2026
Aneuploidy affects cellular immortalization capacity
Mar 31, 2026
Aneuploidy alters cellular metabolic properties
Mar 31, 2026
Aneuploidy alters cellular protein composition approximately twofold
Mar 31, 2026
Aneuploidy and cellular fitness
Mar 31, 2026
Aneuploidy causes proliferative disadvantage independent of extra chromosome identity
Mar 31, 2026
Aneuploidy decreases both organismal and cellular fitness
Mar 31, 2026
Aneuploidy exhibits dual roles as oncogenic and tumor-suppressive
Mar 31, 2026
Aneuploidy heightens sensitivity to protein synthesis interference
Mar 31, 2026
Aneuploidy impairs cell cycle progression in haploid yeast
Mar 31, 2026
Aneuploidy impairs cell proliferation in trisomic lines
Mar 31, 2026
Aneuploidy imposes a fundamental fitness cost through pleiotropic cellular stress
Mar 31, 2026
Aneuploidy imposes a universal proteotoxic stress through stoichiometric imbalance
Mar 31, 2026
Aneuploidy increases glucose uptake in yeast cells
Mar 31, 2026
Aneuploidy increases spontaneous tumor formation in aged animals
Mar 31, 2026
Aneuploidy's dual role in tumorigenesis
Mar 31, 2026
Aneuploidy, fitness costs, and immune evasion
Mar 31, 2026
Approximate Bayesian Computation Framework
Mar 31, 2026
Array CGH detects segmental deletions smaller than 34 Mb
Mar 31, 2026
Array CGH enables aneuploidy screening in preimplantation blastomeres
Mar 31, 2026
Array CGH enables single-cell aneuploidy detection within one day
Mar 31, 2026
Array CGH replaces metaphase spreads with genomic clones on slide
Mar 31, 2026
BAF generation from RNA-seq reads does not require prior variant calls
Mar 31, 2026
Bulk sequencing masks intratumoral copy number heterogeneity
Mar 31, 2026
CENP-E motor protein function
Mar 31, 2026
CENP-E reduction generates aneuploidy and chromosomal instability
Mar 31, 2026
CENP-E
- centromere-protein-E
Mar 31, 2026
CIN causality toward aneuploidy was previously unanswered
Mar 31, 2026
CIN exists independently of classic mitotic defects in most cells
Mar 31, 2026
CaSpER algorithm uses expression and BAF values to estimate CNV events
Mar 31, 2026
Cell cycle gene removal fails to eliminate proliferation confounding
Mar 31, 2026
Chromosomal instability generates immunogenic heterogeneity requiring active immune evasion
Mar 31, 2026
Chromosomal instability promotes immune cell infiltration into tumors
Mar 31, 2026
Chromosome mis-segregation rarely activates p53 independently
Mar 31, 2026
Copy number alterations account for most differential gene expression between NSCs and glioblastoma CSCs
Mar 31, 2026
Copy number variations account for substantial but secondary gene expression variation
Mar 31, 2026
Copy number-independent gene expression differences exist in glioblastoma CSCs
Mar 31, 2026
Copy number-independent gene signature correlates with tumor grade and patient survival
Mar 31, 2026
Different aneuploid cells share common fitness-related traits
Mar 31, 2026
Disseminated tumour cells detected via epithelial markers in mesenchymal tissues
Mar 31, 2026
Elevated merotely generates CIN in stable near-diploid cells
Mar 31, 2026
Established glioblastoma subtype classifiers are variably expressed within tumors
Mar 31, 2026
Evolutionary dynamics of asexual populations
Mar 31, 2026
Evolutionary prediction informative for seasonal influenza across multiple years
Mar 31, 2026
Extra centrosomes correlate with chromosomal instability in tumors
Mar 31, 2026
Extra centrosomes promote chromosome missegregation during bipolar division
Mar 31, 2026
Extra chromosome genes drive aneuploid phenotypes through imbalanced protein composition
Mar 31, 2026
Five-state HMM assigns copy number states and segments genomic regions
Mar 31, 2026
Fixed-size genomic binning enables copy number estimation with limited sequencing depth
Mar 31, 2026
G1-arrested aneuploid cells exhibit elevated p53 and CDK inhibitors
Mar 31, 2026
G1-arrested cells after mis-segregation harbor complex karyotypes
Mar 31, 2026
GC content and mappability independently affect sequence read counts
Mar 31, 2026
Gene expression levels can computationally infer large-scale copy number variations in chromosomally unstable cells
Mar 31, 2026
Gene expression patterns reveal copy number architecture in glioblastoma stem cells
Mar 31, 2026
Gene expression scales proportionally to whole chromosome copy number in chromosomally unstable CSCs
Mar 31, 2026
Gene signature outcome association questionably indicates biological relevance
Mar 31, 2026
Genealogical tree analysis predicts successful strains across asexual populations
Mar 31, 2026
Genealogical tree branching patterns reflect relative fitness differences
Mar 31, 2026
Genealogical tree topology predicts fitness and evolutionary success in evolving populations
Mar 31, 2026
Generalist ABC package accommodates flexible model and algorithm choice
Mar 31, 2026
Glioblastoma cells exhibit continuum of stemness-related expression states
Mar 31, 2026
Growth medium conditions affect aneuploid strain proteome composition
Mar 31, 2026
Human genetic variation architecture
Mar 31, 2026
Hypoxia-related transcriptional programs are variably expressed in glioblastoma cells
Mar 31, 2026
Increased aneuploidy inhibits chemically and genetically induced tumorigenesis
Mar 31, 2026
International HapMap project
- HapMap
Mar 31, 2026
Interrogating both SNPs and CNVs is necessary for understanding complex phenotypes
Mar 31, 2026
Intratumoral Transcriptional Heterogeneity in Glioblastoma
Mar 31, 2026
Merotelic attachments mechanistically link centrosome amplification to chromosomal instability
Mar 31, 2026
Merotely causes chromosome missegregation in unstable cells
Mar 31, 2026
Metric on tree shapes groups phylogenetically similar trees
Mar 31, 2026
Minimal Residual Disease and Metastatic Recurrence
Mar 31, 2026
Missegregation alone insufficient for aneuploid cell propagation
Mar 31, 2026
Mitotic spindle architecture and chromosome segregation
Mar 31, 2026
Most random gene signatures associate with breast cancer outcome
Mar 31, 2026
Mps1 truncation-induced CIN generates convergent recurrent chromosome gains
Mar 31, 2026
Multipolar divisions are rare and typically produce inviable progeny
Mar 31, 2026
Multipolar spindle intermediate allows merotelic attachment accumulation
Mar 31, 2026
Multiscale BAF smoothing improves CNV call assignment accuracy
Mar 31, 2026
Neural stem cells and glioblastoma CSCs have distinct transcriptome profiles
Mar 31, 2026
Nonlinear heteroscedastic regression improves ABC parameter estimation accuracy
Mar 31, 2026
PCR duplicate filtering and mapping quality threshold improve sequence read quality
Mar 31, 2026
Persistent fitness variation exists among circulating influenza viruses
Mar 31, 2026
Phylogenetic metrics distinguish trees from different generative processes
Mar 31, 2026
Phylogenetic tree shape as macroevolutionary signal
Mar 31, 2026
Phylogenetic tree shape quantifies macroevolutionary dynamics across temporal scales
Mar 31, 2026
Phylogenetic tree shape reflects macroevolutionary processes
Mar 31, 2026
Primary glioblastomas contain inherent variability in oncogenic signaling expression
Mar 31, 2026
Proliferation and immune response programs vary across individual glioblastoma cells
Mar 31, 2026
Proliferation confounding in gene signatures
Mar 31, 2026
Proliferation confounds gene signature outcome association
Mar 31, 2026
Protein levels correlate with chromosomal position in aneuploid strains
Mar 31, 2026
Protein stoichiometry tracks gene dosage in aneuploid cells with high fidelity
Mar 31, 2026
Proteome consequences of aneuploidy
Mar 31, 2026
Published breast cancer signatures not better than random signatures
Mar 31, 2026
Quantitative proteomics measures 70-80% of yeast open reading frames
Mar 31, 2026
Recursive median filtering and multiscale decomposition smooth expression signal noise
Mar 31, 2026
Resolving subclonal heterogeneity improves clinical trial design
Mar 31, 2026
Root node label uniquely defines binary tree shape
Mar 31, 2026
SAC inactivation accelerates mitosis despite incorrect chromosome attachment
Mar 31, 2026
SNP and CNV signals show minimal overlap in gene expression associations
Mar 31, 2026
SNPs and CNVs contribute independently to gene expression architecture
Mar 31, 2026
SNPs capture majority of genetic variation affecting gene expression
Mar 31, 2026
Shallow whole-genome sequencing detects copy number alterations in tumor samples
Mar 31, 2026
Simultaneous correction of GC content and mappability improves read count accuracy
Mar 31, 2026
Single cells show unique chromosome copy numbers beyond clonal karyotype
Mar 31, 2026
Single-cell resolution exposes artifactual structure in population-level molecular signatures
Mar 31, 2026
Single-cell sequencing reveals karyotype heterogeneity in lymphomas
Mar 31, 2026
Small effect mutations accumulate during asexual population evolution
Mar 31, 2026
Small primary tumours with minimal residual disease show metastatic relapse
Mar 31, 2026
Stat1 inactivation mechanism is conserved between mouse and human aneuploid cancers
Mar 31, 2026
Stat1 loss combined with Myc activation alleviates CIN-induced immune infiltration
Mar 31, 2026
Strong expression signal events require no BAF corroboration for CNV calls
Mar 31, 2026
Subclonal Dynamics in Cancer Evolution
Mar 31, 2026
Subclonal driver events determine therapy response and tumor evolution
Mar 31, 2026
Tree asymmetry relates to frequency of symmetric cherry subtrees
Mar 31, 2026
Tree balance and branch length distribution characterize tree shape
Mar 31, 2026
Tree shape associates evolutionary rate changes with ecological causes
Mar 31, 2026
Tree shape detects mass extinctions and adaptive radiations
Mar 31, 2026
Tree shape measures variation in speciation and extinction rates
Mar 31, 2026
Tree shape metrics encode evolutionary process through structural features
Mar 31, 2026
Tree topology characterization and metrics
Mar 31, 2026
Tumor heterogeneity and stemness dynamics
Mar 31, 2026
Tumors contain multiple subclones with spatial and temporal heterogeneity
Mar 31, 2026
User-defined data simulation enables generalist ABC implementation
Mar 31, 2026
Weak expression signal events require BAF shifts for CNV confirmation
Mar 31, 2026
Whole genome amplification enables single-cell array CGH analysis
Mar 31, 2026
accuracy
Mar 31, 2026
adaptive radiations
Mar 31, 2026
adjuvant therapy
Mar 31, 2026
algorithms
Mar 31, 2026
anaphase
Mar 31, 2026
aneuploid cells
Mar 31, 2026
aneuploid yeast
Mar 31, 2026
aneuploid
Mar 31, 2026
aneuploidy induced stress
Mar 31, 2026
approximate bayesian computation (abc)
- ABC
Mar 31, 2026
asexual population
Mar 31, 2026
basic reproduction number
- R₀
Mar 31, 2026
bayesian analysis
Mar 31, 2026
bijective mapping
Mar 31, 2026
binary tree
Mar 31, 2026
biogeographical causes
Mar 31, 2026
biological mechanism
Mar 31, 2026
bipolar cell division
- bipolar-division
Mar 31, 2026
bipolar spindle assembly
Mar 31, 2026
birth death process
- BD-process
Mar 31, 2026
branch lengths
Mar 31, 2026
branching pattern
Mar 31, 2026
breast cancer outcome
Mar 31, 2026
cancer stem cells
Mar 31, 2026
cancer
Mar 31, 2026
cell cycle defects
Mar 31, 2026
cell cycle genes
Mar 31, 2026
cell cycle progression
Mar 31, 2026
cell proliferation
Mar 31, 2026
cellular fitness
Mar 31, 2026
centromere
Mar 31, 2026
centrosome clustering
Mar 31, 2026
centrosomes
- centrosome
- MTOC
Mar 31, 2026
chemical carcinogens
Mar 31, 2026
cherry
Mar 31, 2026
chromosomal imbalance
Mar 31, 2026
chromosomal instability
- CIN
Mar 31, 2026
chromosomal position
Mar 31, 2026
chromosomally unstable tumors
- CIN-tumors
Mar 31, 2026
chromosome duplication
Mar 31, 2026
chromosome loss
Mar 31, 2026
chromosome missegregation
Mar 31, 2026
chromosome number
Mar 31, 2026
circulating
Mar 31, 2026
clade
Mar 31, 2026
clinical trial
Mar 31, 2026
complement
Mar 31, 2026
complex models
Mar 31, 2026
complex phenotypes
Mar 31, 2026
confounding effect
Mar 31, 2026
confounding variables
Mar 31, 2026
confounding
Mar 31, 2026
copy number variations (CNVs)
- CNVs
Mar 31, 2026
copy number
Mar 31, 2026
cross validation
Mar 31, 2026
data simulation
Mar 31, 2026
diploid
Mar 31, 2026
disease susceptibility
Mar 31, 2026
disomic strains
Mar 31, 2026
disseminated tumour cells
- DTCs
Mar 31, 2026
driver events
Mar 31, 2026
driver mutations
Mar 31, 2026
duplicated chromosomes
Mar 31, 2026
ecological causes
Mar 31, 2026
epithelial markers
Mar 31, 2026
euploid cells
Mar 31, 2026
euploid
Mar 31, 2026
evolution
Mar 31, 2026
evolutionary divergences
Mar 31, 2026
evolutionary prediction
Mar 31, 2026
expression states
Mar 31, 2026
extant taxa
Mar 31, 2026
extinction rates
Mar 31, 2026
fitness variation
Mar 31, 2026
fitness
Mar 31, 2026
fossil record
Mar 31, 2026
gene dosage
Mar 31, 2026
gene expression marker
- signature
Mar 31, 2026
gene expression variability
Mar 31, 2026
gene expression
Mar 31, 2026
genealogical pattern
Mar 31, 2026
genetic alterations
Mar 31, 2026
genetic variation
Mar 31, 2026
glioblastoma subtype classifiers
Mar 31, 2026
glucose uptake
Mar 31, 2026
growth medium
Mar 31, 2026
haploid yeast
Mar 31, 2026
hazard ratio
Mar 31, 2026
hypoxia
Mar 31, 2026
immortalization
Mar 31, 2026
immune cell infiltration
- immune-infiltration
Mar 31, 2026
immune response
Mar 31, 2026
immune surveillance
Mar 31, 2026
in vitro
Mar 31, 2026
in vivo
Mar 31, 2026
inference
Mar 31, 2026
influenza A/H3N2 virus
Mar 31, 2026
influenza season
Mar 31, 2026
intratumoral heterogeneity
Mar 31, 2026
kinetochore
Mar 31, 2026
lagging chromosomes
Mar 31, 2026
likelihood function
Mar 31, 2026
lineage
Mar 31, 2026
liquid chromatography—tandem mass spectrometry
- LC-MS/MS
Mar 31, 2026
local treatment
Mar 31, 2026
log2 ratios
Mar 31, 2026
longitudinal dynamics
Mar 31, 2026
lymphomas
Mar 31, 2026
macroevolutionary phenomena
Mar 31, 2026
macroevolutionary processes
Mar 31, 2026
malignancy
Mar 31, 2026
mass extinctions
Mar 31, 2026
merotely
Mar 31, 2026
mesenchymal tissues
Mar 31, 2026
metabolic properties
Mar 31, 2026
metagene
Mar 31, 2026
metastasis
Mar 31, 2026
metastatic relapse
Mar 31, 2026
metric
Mar 31, 2026
microenvironment
Mar 31, 2026
microtubule chromosome attachment
Mar 31, 2026
microtubule
Mar 31, 2026
minimal residual disease
- MRD
Mar 31, 2026
mitosis
Mar 31, 2026
model selection
Mar 31, 2026
models
Mar 31, 2026
molecular subtypes
Mar 31, 2026
motor protein
Mar 31, 2026
multidimensional scaling
- MDS
Mar 31, 2026
multipolar cell division
- multipolar-division
Mar 31, 2026
multipolar spindle intermediate
Mar 31, 2026
multipolar spindles
Mar 31, 2026
mutation
Mar 31, 2026
myc activation
- Myc-activity
Mar 31, 2026
node label
Mar 31, 2026
node labeling
Mar 31, 2026
nonlinear heteroscedastic regression
Mar 31, 2026
oncogenic signaling
Mar 31, 2026
oncogenic
Mar 31, 2026
open reading frames
- ORFs
Mar 31, 2026
organismal fitness
Mar 31, 2026
outcome association
Mar 31, 2026
outcome predictor
Mar 31, 2026
p53 inactivation
Mar 31, 2026
p53 loss is common but not enriched in chromosomally unstable tumors
Mar 31, 2026
parameter estimation
Mar 31, 2026
phenotype
Mar 31, 2026
phenotypic changes
Mar 31, 2026
phylogenetic metric
Mar 31, 2026
phylogenetic tree
Mar 31, 2026
precision medicine
Mar 31, 2026
primary glioblastoma
Mar 31, 2026
primary tumour
Mar 31, 2026
progenitor lineage
Mar 31, 2026
prognostic implications
Mar 31, 2026
proliferation marker
Mar 31, 2026
proliferative disadvantage
Mar 31, 2026
protein abundance
Mar 31, 2026
protein composition
Mar 31, 2026
protein folding
Mar 31, 2026
protein production
Mar 31, 2026
proteome
Mar 31, 2026
putative regulators
Mar 31, 2026
random signature
Mar 31, 2026
relative fitness
Mar 31, 2026
replicative senescence
Mar 31, 2026
root node
Mar 31, 2026
scWGS platform detects copy number variants via shallow sequencing
Mar 31, 2026
seasonal influenza
Mar 31, 2026
selection pressure
Mar 31, 2026
sensitivity
Mar 31, 2026
sequence
Mar 31, 2026
silac
- stable-isotope-labeling-of-amino-acids-in-cell-culture
Mar 31, 2026
single cell rna seq
- scRNA-seq
- single-cell-RNA-sequencing
Mar 31, 2026
single nucleotide polymorphisms (SNPs)
- SNPs
Mar 31, 2026
small effect mutations
Mar 31, 2026
spatial distribution
Mar 31, 2026
spatial heterogeneity
Mar 31, 2026
speciation rates
Mar 31, 2026
spindle assembly checkpoint
Mar 31, 2026
spontaneous tumor formation
Mar 31, 2026
stat1 inactivation
Mar 31, 2026
stat1 signaling
Mar 31, 2026
statistical association
Mar 31, 2026
statistical significance
Mar 31, 2026
stemness
Mar 31, 2026
strain
Mar 31, 2026
subclone
- tumor-subclone
Mar 31, 2026
subtree
Mar 31, 2026
summary statistics
Mar 31, 2026
symmetric configuration
Mar 31, 2026
systemic treatment
Mar 31, 2026
temporal distribution
Mar 31, 2026
temporal heterogeneity
Mar 31, 2026
therapy response
Mar 31, 2026
tmt mass spectrometry
- tandem-mass-tag-mass-spectrometry
- isobaric-tandem-mass-tag
Mar 31, 2026
transcript
Mar 31, 2026
transcriptional programs
Mar 31, 2026
transcriptome
Mar 31, 2026
tree asymmetry
Mar 31, 2026
tree balance
Mar 31, 2026
tree imbalance
Mar 31, 2026
tree isomorphism
Mar 31, 2026
tree shape
Mar 31, 2026
trisomic cells
Mar 31, 2026
tumor cells
Mar 31, 2026
tumor evolution
Mar 31, 2026
tumor suppression
Mar 31, 2026
tumor suppressor
Mar 31, 2026
tumor
Mar 31, 2026
tumorigenesis
Mar 31, 2026
tumors
Mar 31, 2026
wild type cells
Mar 31, 2026
yule model
- Yule-process

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Folder: concepts