Deciphering the spatial and temporal distribution of subclones and their associated driver mutations provides information that can optimize the design and execution of clinical trials. This knowledge of intratumoral heterogeneityintratumor heterogeneity allows for better patient stratification and treatment selection in precision medicine approaches. [@hiley_deciphering_2014]
Definitions
- subclone
- intratumoral heterogeneityintratumor heterogeneity
- spatial distribution
- temporal distribution
- driver mutations
- clinical trial
- precision medicine