Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
Authors: Hiley, Crispin and de Bruin, Elza C. and McGranahan, Nicholas and Swanton, Charles Year: 2014 Journal: Genome Biology
Abstract
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.