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merotely

merotely

Mar 31, 20261 min read

An abnormal microtubule–chromosome attachment in which a single kinetochore is attached to microtubules from both spindle poles.

An erroneous kinetochore-microtubule attachment in which a single kinetochore is attached to microtubules originating from both spindle poles.

Related Claims

  • Merotely causes chromosome missegregation in unstable cells
  • Elevated merotely generates CIN in stable near-diploid cells

Graph View

Backlinks

  • Aneuploidy's dual role in tumorigenesis
  • CENP-E motor protein function
  • CENP-E reduction generates aneuploidy and chromosomal instability
  • CIN causality toward aneuploidy was previously unanswered
  • CIN exists independently of classic mitotic defects in most cells
  • Elevated merotely generates CIN in stable near-diploid cells
  • Merotelic attachments mechanistically link centrosome amplification to chromosomal instability
  • Merotely causes chromosome missegregation in unstable cells
  • Missegregation alone insufficient for aneuploid cell propagation
  • Mitotic spindle architecture and chromosome segregation
  • Multipolar spindle intermediate allows merotelic attachment accumulation
  • chromosomal instability

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