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stat1 inactivation

stat1 inactivation

Mar 31, 20261 min read

Loss or reduction of function of the Stat1 signaling molecule, a transcription factor in interferon response pathways.

Related Claims

  • Stat1 loss combined with Myc activation alleviates CIN-induced immune infiltration
  • p53 loss is common but not enriched in chromosomally unstable tumors
  • Stat1 inactivation mechanism is conserved between mouse and human aneuploid cancers
  • Aneuploid cancers inactivate Stat1 to circumvent immune surveillance

Related

  • stat1 signaling

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  • Related Claims
  • Related

Backlinks

  • Aneuploid cancers inactivate Stat1 to circumvent immune surveillance
  • Aneuploidy, fitness costs, and immune evasion
  • CENP-E reduction generates aneuploidy and chromosomal instability
  • Chromosomal instability generates immunogenic heterogeneity requiring active immune evasion
  • Increased aneuploidy inhibits chemically and genetically induced tumorigenesis
  • Missegregation alone insufficient for aneuploid cell propagation
  • Mps1 truncation-induced CIN generates convergent recurrent chromosome gains
  • Stat1 inactivation mechanism is conserved between mouse and human aneuploid cancers
  • Stat1 loss combined with Myc activation alleviates CIN-induced immune infiltration
  • Subclonal driver events determine therapy response and tumor evolution
  • Tumors contain multiple subclones with spatial and temporal heterogeneity
  • aneuploid
  • fitness
  • p53 loss is common but not enriched in chromosomally unstable tumors
  • stat1 signaling

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