Multiscale BAF smoothing improves CNV call assignment accuracy

CaSpER smooths the BAF shift signal using M-level multiscale decomposition with increasing window lengths between consecutive scales. This multiscale approach to BAF signal processing allows for better integration with the HMM-assigned copy number states to generate final CNV calls with improved accuracy. [@serin_harmanci_casper_2020]

Definitions

• accuracy

Bibliography

• CaSpER identifies and visualizes CNV events by integrative analysis of single-cell or bulk RNA-sequencing data