When chromosome mis-segregation is induced through SAC inactivation rather than SAC activation, the resulting aneuploid cells do not arrest in the subsequent G1 phase in approximately 80% of cases, indicating that the aneuploid state itself does not reliably trigger p53-dependent cell cycle arrest. This contrasts with previous findings that used SAC-activation methods which confounded prolonged mitotic arrest with chromosome segregation defects. [@santaguida_chromosome_2017]