A subset of tumor cells with stem cell-like properties including self-renewal capacity and the ability to differentiate into multiple cell types within the tumor.
Related Claims
- Glioblastoma cells exhibit continuum of stemness-related expression states
- Gene expression scales proportionally to whole chromosome copy number in chromosomally unstable CSCs
- Copy number alterations account for most differential gene expression between NSCs and glioblastoma CSCs
- Copy number-independent gene expression differences exist in glioblastoma CSCs
- Copy number-independent gene signature correlates with tumor grade and patient survival
- Neural stem cells and glioblastoma CSCs have distinct transcriptome profiles