The genetic signals from SNPs and CNVs that associate with gene expression variation have little overlap, indicating that these two types of genetic variation affect gene expression through distinct or non-overlapping mechanisms. This suggests that the variation captured by each type provides independent information about gene expression determinants. [@stranger_relative_2007]
Definitions
- single nucleotide polymorphisms (SNPs)
- copy number variations (CNVs)
- gene expression
- genetic variation