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chromosomally unstable tumors

chromosomally unstable tumors

Mar 31, 20261 min read

  • CIN-tumors

Tumors exhibiting elevated rates of chromosome mis-segregation and aneuploidy during cell division.

Related Claims

  • Aneuploid tumors inactivate Stat1 signaling with increased Myc activity
  • Chromosomal instability promotes immune cell infiltration into tumors
  • p53 loss is common but not enriched in chromosomally unstable tumors

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Backlinks

  • Aneuploid cancers inactivate Stat1 to circumvent immune surveillance
  • Aneuploid tumors inactivate Stat1 signaling with increased Myc activity
  • Aneuploidy, fitness costs, and immune evasion
  • Chromosomal instability generates immunogenic heterogeneity requiring active immune evasion
  • Chromosomal instability promotes immune cell infiltration into tumors
  • Different aneuploid cells share common fitness-related traits
  • Extra centrosomes correlate with chromosomal instability in tumors
  • Single-cell sequencing reveals karyotype heterogeneity in lymphomas
  • Stat1 inactivation mechanism is conserved between mouse and human aneuploid cancers
  • Stat1 loss combined with Myc activation alleviates CIN-induced immune infiltration
  • Subclonal driver events determine therapy response and tumor evolution
  • p53 loss is common but not enriched in chromosomally unstable tumors
  • tumors

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