Andrew's Notes

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microtubule

Mar 31, 20261 min read

A structural polymer composed of α- and β-tubulin dimers that forms part of the cellular cytoskeleton and organizes the mitotic spindle.

CENP-E motor protein function
CENP-E reduction generates aneuploidy and chromosomal instability
CIN exists independently of classic mitotic defects in most cells
Elevated merotely generates CIN in stable near-diploid cells
Extra centrosomes promote chromosome missegregation during bipolar division
Merotelic attachments mechanistically link centrosome amplification to chromosomal instability
Merotely causes chromosome missegregation in unstable cells
Mitotic spindle architecture and chromosome segregation
Multipolar spindle intermediate allows merotelic attachment accumulation
chromosomal instability
chromosome missegregation