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transcriptional programs

transcriptional programs

Mar 31, 20261 min read

Coordinated sets of genes that are regulated together to implement specific cellular functions or responses.

Related Claims

  • Primary glioblastomas contain inherent variability in oncogenic signaling expression
  • Proliferation and immune response programs vary across individual glioblastoma cells
  • Hypoxia-related transcriptional programs are variably expressed in glioblastoma cells

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  • Established glioblastoma subtype classifiers are variably expressed within tumors
  • Hypoxia-related transcriptional programs are variably expressed in glioblastoma cells
  • Intratumoral Transcriptional Heterogeneity in Glioblastoma
  • Neural stem cells and glioblastoma CSCs have distinct transcriptome profiles
  • Primary glioblastomas contain inherent variability in oncogenic signaling expression
  • Proliferation and immune response programs vary across individual glioblastoma cells
  • Single-cell resolution exposes artifactual structure in population-level molecular signatures
  • Tumors contain multiple subclones with spatial and temporal heterogeneity
  • cell proliferation
  • gene expression
  • intratumoral heterogeneity
  • tumor
  • tumors

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