Aneuploid haploid yeast strains demonstrate increased glucose uptake compared to euploid controls. This increased glucose consumption occurs consistently across strains bearing different extra chromosomes, suggesting it is a general physiological consequence of the aneuploidaneuploidy condition rather than specific to particular genes. [@torres_effects_2007]
Definitions
Synthesis
Aneuploid yeast cells carrying extra chromosomes exhibit increased glucose uptake compared to euploid cells, a phenotype that appears consistently across strains with different chromosomal duplications. This metabolic alteration is driven mechanistically by the additional protein production from genes on the extra chromosomes, which creates stoichiometric imbalances in cellular protein composition that impose proteotoxic stress on the cell. The increased glucose uptake likely represents a compensatory metabolic response to the energetic demands of managing protein imbalance, as aneuploid cells simultaneously show impaired cell cycle progression and heightened sensitivity to protein synthesis interference. While it is established that this glucose uptake phenotype stems from general consequences of aneuploidy rather than specific gene dosage effects, the precise signaling pathways linking proteotoxic stress to altered glucose metabolism remain unresolved.
Related
- Aneuploidy impairs cell cycle progression in haploid yeast
- Extra chromosome genes drive aneuploid phenotypes through imbalanced protein composition
- Aneuploidy heightens sensitivity to protein synthesis interference
- Aneuploidy causes proliferative disadvantage independent of extra chromosome identity