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chromosomal imbalance

chromosomal imbalance

Mar 31, 20261 min read

A condition in which the normal proportion or copy number of chromosomes is disrupted.

Related Claims

  • Aneuploidy decreases both organismal and cellular fitness
  • Different aneuploid cells share common fitness-related traits
  • Whole genome amplification enables single-cell array CGH analysis

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Backlinks

  • Aneuploidy and cellular fitness
  • Aneuploidy decreases both organismal and cellular fitness
  • Aneuploidy exhibits dual roles as oncogenic and tumor-suppressive
  • Aneuploidy impairs cell cycle progression in haploid yeast
  • Aneuploidy impairs cell proliferation in trisomic lines
  • Aneuploidy imposes a fundamental fitness cost through pleiotropic cellular stress
  • Different aneuploid cells share common fitness-related traits
  • Missegregation alone insufficient for aneuploid cell propagation
  • Mps1 truncation-induced CIN generates convergent recurrent chromosome gains
  • Stat1 loss combined with Myc activation alleviates CIN-induced immune infiltration
  • Whole genome amplification enables single-cell array CGH analysis
  • aneuploid cells
  • cell proliferation
  • fitness
  • phenotype

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